Multiple myeloma research shows promise 

UAMS press release

A discovery stemming from multiple myeloma research at the University of Arkansas for Medical Sciences (UAMS) could lead to significant new treatments for bone-related cancers and diseases such as rheumatoid arthritis and osteoporosis.

The research by John D. Shaughnessy Jr., Ph.D., in the UAMS Myeloma Institute for Research and Therapy (MIRT), led to applications for two patents related to a molecule found to be the key to bone destruction.

“The dream of any medical researcher is to see a discovery lead to the development of a new therapy,” said Shaughnessy, director of the basic science division of MIRT. “Even more satisfying is the realization that our discovery might impact not only multiple myeloma but other diseases.”

Through UAMS BioVentures, the patents pending have been licensed to a pharmaceutical company. While specific terms of the license agreement remain confidential, UAMS will receive annual payments until the first commercial sale, then a percentage of drug sales.

Shaughnessy’s research has shown promising lab results for blunting the molecule’s ability to destroy bone and even cause regression of tumors, as well as increasing bone density in bones without tumors.

In addition to multiple myeloma, the research could lead to treatments for other metabolic or cancer-related bone diseases.

Shaughnessy’s original research discovery on the molecule was published in the December 25, 2003, issue of the New England Journal of Medicine. Using state-of-the-art genomic profiling methods, Shaughnessy and other researchers from MIRT and the UAMS Arkansas Cancer Research Center also discovered that myeloma is not a single disease but consists of distinct subtypes that Shaughnessy predicted will improve the diagnosis, prognosis and treatment of patients. That study was published in the September 2006 issue of the journal Blood.

UAMS BioVentures, which negotiated the licensing agreement, was formed a decade ago to help UAMS researchers get their discoveries into the marketplace, whether through licensing agreements or forming start-up companies.

“The discoveries by Dr. Shaughnessy and his team of scientists are producing intellectual property that is of tremendous value to medicine for the delivery of better health care,” said BioVentures director Michael Douglas, Ph.D. “UAMS and Arkansas are fortunate to have a medical research enterprise that can deliver discovery and intellectual property with great potential in the marketplace.”

In addition to assisting with licensing of UAMS intellectual property, BioVentures has helped numerous start-up companies get UAMS-generated products to consumers. Its efforts have led to the establishment of companies providing 316 highly skilled jobs, a total annual payroll today of $15.7 million and salaries that average $49,638 a year.


Speaking of Medical News


Subscribe to this thread:

Add a comment

More by Arkansas Times Staff

Most Shared

  • Welfare for the wealthy: More reasons to VOTE NO on ISSUE 3

    Voices on the left and right are lifted against Issue 3, the corporate welfare amendment to send tax money to private business and corporate lobbyists.
  • Little Rock police kill man downtown

    Little Rock police responding to a disturbance call near Eighth and Sherman Streets about 12:40 a.m. killed a man with a long gun, Police Chief Kenton Buckner said in an early morning meeting with reporters.
  • From the mind of Sol LeWitt: Crystal Bridges 'Loopy Doopy': A correction

    Crystal Bridges Museum of American Art is installing Sol Lewitt's 70-foot eye-crosser "Wall Drawing 880: Loopy Doopy," waves of complementary orange and green, on the outside of the Twentieth Century Gallery bridge. You can glimpse painters working on it from Eleven, the museum's restaurant, museum spokeswoman Beth Bobbitt said

Latest in Medical Community

  • UAMS earns 10-year reaccreditation

    The University of Arkansas for Medical Sciences (UAMS) recently learned that it has been reaccredited another 10 years by the Higher Learning Commission of the North Central Association of Colleges and Schools.
    • Oct 16, 2007
  • UAMS performs 7,000th stem-cell transplant

    The internationally known treatment program for multiple myeloma at the University of Arkansas for Medical Sciences (UAMS) reached another milestone today (Oct. 10) as Jeffrey Zwerin of California received the 7,000th stem-cell transplant procedure perfor
    • Oct 10, 2007
  • Richard Morrison receives endowed chair

    Richard P. Morrison, M.D., today became the inaugural recipient of the Chair in Sciences Basic to Medicine at the University of Arkansas for Medical Sciences (UAMS).
    • Oct 9, 2007
  • More »

Visit Arkansas

Searching for diamonds at Crater of Diamonds State Park

Searching for diamonds at Crater of Diamonds State Park

A venture to this state park is on the must-do list for many, the park being the only spot in North America where you can dig for diamonds and other gemstones and keep your finds.

Event Calendar

« »


2 3 4 5 6 7 8
9 10 11 12 13 14 15
16 17 18 19 20 21 22
23 24 25 26 27 28 29
30 31  

Most Viewed

  • Leslie Rutledge, the absent attorney general

    Arkansas loses out to Trump love, Obama hate.
  • Left and right against Issue 3

    Also, Huck spinning on Trump, not in our backyard and more.
  • Thanks!

    In less than two weeks, We the People are about to roll the dice and elect our next president. Just enough time left to dash off a few well-deserved thank you notes ... .
  • Trump country

    Even in deep red Arkansas, Trump could damage some down-ballot Republicans — but will boost others.
  • Moving

    The Observer will be moving soon. Not out of The Observatory, thank God, as we're sure it will take the wagon from the 20 Mule Team Borax box to get us away from there after 14 years of accumulation, plus a team of seasoned Aussie wildlife wranglers to herd our pair of surly wildcats into a crate. No, just out of the office we've been in at the Fortress of Employment for going on five years, which is bad enough. We're moving to the other side of the building here in a few months.

Most Recent Comments

  • Re: Leslie Rutledge, the absent attorney general

    • Chastised for loving her state and country! Left will b left.

    • on October 26, 2016
  • Re: Road Trip Arkansas

    • Hunter . I see what you mean... Charles `s comment is unimaginable... I just got…

    • on October 25, 2016
  • Re: The Arkansas ale trail

    • just before I saw the draft that said $7003 , I didn't believe that...my... friend…

    • on October 25, 2016

© 2016 Arkansas Times | 201 East Markham, Suite 200, Little Rock, AR 72201
Powered by Foundation